Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: No effect of omeprazole on pH of exhaled breath condensate in cough associated with gastro-oesophageal reflux. | Cough BioMed Central Research Open Access No effect of omeprazole on pH of exhaled breath condensate in cough associated with gastro-oesophageal reflux Alfonso Torrego Stefan Cimbollek Mark Hew and Kian Fan Chung Address Department of Thoracic Medicine National Heart Lung Institute Imperial College and Royal Brompton Hospital London UK Email Alfonso Torrego - Stefan Cimbollek - scimbollek@ Mark Hew - Kian Fan Chung - Corresponding author Published 19 October 2005 Received 21 June 2005 Cough 2005 1 10 doi 1745-9974-1-10 Accepted 19 October 2005 This article is available from http content 1 1 10 2005 Torrego et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Endogenous airway acidification evaluated as pH in exhaled breath condensate EBC has been described in patients with chronic cough. Proton pump inhibitors improve gastro-oesophageal reflux GOR -associated cough. Methods We examined pH levels in EBC and capsaicin cough response in 1 3 patients with chronic cough mean age 41 years SD 9 associated with GOR before and after omeprazole treatment 40 mg day for 14 days and its relationship with clinical response. Results Omeprazole abolished symptoms associated with GOR. Patients with chronic cough had an EBC pH of SD prior to treatment but this did not change with omeprazole treatment. There was a significant improvement in the Leicester Cough Questionnaire symptom scores from points SD to SD 17 p and in a 6-point scale of cough scores but there was no change in capsaicin cough response. Conclusion An improvement in GOR-associated cough was not associated with changes in EBC
