Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Cough reflex and oral chemesthesis induced by capsaicin and capsiate in healthy never-smokers. | Cough BioMed Central Research Open Access Cough reflex and oral chemesthesis induced by capsaicin and capsiate in healthy never-smokers Miyako Yamasaki Satoru Ebihara Takae Ebihara Shannon Freeman Shinsuke Yamanda Masanori Asada Motoki Yoshida and Hiroyuki Arai Address the Department of Geriatrics and Gerontology Tohoku University School of Medicine Seiryo-cho 1-1 Aoba-ku Sendai 980-8574 Japan Email Miyako Yamasaki - ymsk@ Satoru Ebihara - s_ebihara@ Takae Ebihara - takae_montreal@ Shannon Freeman - shannon2@ Shinsuke Yamanda - fullback15@ Masanori Asada - asada@ Motoki Yoshida - m-yoshida@ Hiroyuki Arai - satoru_montreal@ Corresponding author Published 31 October 2007 Received 7 June 2007 Cough 2007 3 9 doi l745-9974-3-9 Accepted 31 October 2007 This article is available from http content 3 1 9 2007 Yamasaki et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Many tussive agents are components of foods but little is known about the relationship between cough reflex and oral chemesthesis sensitivities. We investigated the relationships between cough reflex and oral chemesthesis in individuals using two transient receptor potential vanilloid 1 TRPV1 agonists with different potencies capsaicin and capsiate. Methods Twenty-eight healthy never-smokers were allocated to evaluate cough and oral chemesthesis of capsinoids. Cough reflex sensitivities are estimated by the lowest concentrations generating five coughs by each TRPV1 agonist inhalation. Oral chemesthesis sensitivities are estimated by the lowest concentrations which generate a hot .
