Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Measuring cough severity: Perspectives from the literature and from patients with chronic cough. | Cough BioMed Central Research Measuring cough severity Perspectives from the literature and from patients with chronic cough Margaret Vernon 1 Nancy Kline Leidy11 Alise Nacson11 and Linda Nelsen12 Open Access Address United BioSource Corporation Bethesda MD USA and 2Merck Co Inc North Wales PA USA Email Margaret Vernon - Nancy Kline Alise Nacson - alisenacson@ Linda Nelsen - linda_nelsen@ Corresponding author tEqual contributors Published 19 March 2009 Received 19 November 2008 Cough 2009 5 5 doi l745-9974-5-5 Accepted 19 March 2009 This article is available from http content 5 1 5 2009 Vernon et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In order to assess severity of cough from patients perspectives and capture the effects of treatment in clinical trials a measurement tool must show evidence of validity and reliability. The purpose of this study was to characterize cough severity from patients perspectives as the initial step in the development of a new patient-reported outcome PRO measure for use in clinical trials. Methods This focus groups study included patients with clinician confirmed chronic cough recruited from a large internal medicine clinic in the US. A semi-structured focus group guide was designed to elicit information about patients experiences with cough severity and their characterization of symptoms. The focus group data were coded to identify concepts and terminology of cough severity. Results Three focus groups were conducted n 22 6 male mean age . Etiology included GERD asthma bronchitis post-nasal drip and other. Three domains of cough severity
