Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Longitudinal increases in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients. | Available online http content 11 4 R88 Research Longitudinal increases in mitochondrial DNA levels in blood cells are associated with survival in critically ill patients Hélène CF Côté1 Andrew G Day2 and Daren K Heyland3 Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada V6T 2B5 2Clinical Research Centre Kingston General Hospital Kingston Canada K7L 2V7 department of Medicine Queen s University and Critical Care Program Kingston General Hospital Kingston Canada K7L 2V7 Corresponding author Hélène CF Côté Received 29 Jun 2007 Revisions requested 19 Jul 2007 Revisions received 10 Aug 2007 Accepted 15 Aug 2007 Published 15 Aug 2007 Critical Care 2007 11 R88 doi cc6096 This article is online at http content 11 4 R88 2007 Côté et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. See related commentary by Deutschman and Levy http content 11 4 158 Open Access Abstract Background Mitochondrial dysfunction may be causally related to the pathogenesis of organ failure in critically ill patients. Decreased mitochondrial DNA mtDNA levels have been associated with mitochondrial dysfunction and were investigated here in relation to short-term 31-day survival. Methods This was a prospective longitudinal cohort study of 28 mechanically ventilated critically ill adults admitted to a single center tertiary care intensive care unit ICU with hypotension secondary to cardiogenic N 13 septic N 14 or hypovolemic N 1 disease processes. Clinical data and blood were collected at baseline and patients were followed until they expired or left the ICU. Blood was collected every Monday Wednesday and Friday and the buffycoat relative mtDNA nuclear
