Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Novel biomarkers in critical care: utility or futility? | Available online http content 11 6 175 Commentary Novel biomarkers in critical care utility or futility Gareth L Ackland1 and Michael G Mythen2 Centre for Anaesthesia Critical Care and Pain Management University College London 2Smiths Medical Chair of Anaesthesia and Critical Care University College London Corresponding author Gareth L Ackland Published 7 November 2007 This article is online at http content 11 6 175 2007 BioMed Central Ltd Critical Care 2007 11 175 doi cc6127 See related research by Fellahi et al. http content 11 5 R106 Abstract One of the holy grails of modern medicine across a range of clinical sub-specialties is establishing highly sensitive and specific biomarkers for various diseases. Significant success has been achieved in some of these clinical areas most notably identifying high-sensitivity C-reactive peptide troponin I T and brain natriuretic peptide as significant prognosticators for both the acute outcome and the development of cardiovascular pathology. However it is highly debatable whether this translates to complex multi-system pathophysiological insults. Is critical care immune from the application of these novel biomarkers given the numerous confounding factors interfering with their interpretation In the previous issue of Critical Care 1 Fellahi and colleagues in a large observational study describe troponin-I release in three cohorts of cardiac surgical patients undergoing bypass grafts valve replacement s or both. They report that patients undergoing both valve and bypass graft procedures sustained more cardiac damage but the troponin-threshold for clinically significant events was higher in these patients. There are no cardiac tissue samples or serial echocardiographic data to provide histopathological and or physiologic corroboration of these findings. On face value these results are perhaps not surprising given that intuitively greater cardiac tissue damage .
