Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: The inflammation-perpetuating . | Available online http content 12 1 201 Review Bench-to-bedside review The inflammation-perpetuating patternrecognition receptor RAGE as a therapeutic target in sepsis Christian Bopp1 Angelika Bierhaus2 Stefan Hofer1 Axel Bouchon3 Peter P Nawroth2 Eike Martin1 and Markus A Weigand1 1 Department of Anesthesiology University of Heidelberg Im Neuenheimer Feld 110 69120 Heidelberg Germany 2Department of Medicine I University of Heidelberg Im Neuenheimer Feld 410 69120 Heidelberg Germany 3Bayer CropScience Alfred-Nobel-Str. 50 40789 Monheim Germany Corresponding author Markus A Weigand Published 9 January 2008 This article is online at http content 12 1 201 2008 BioMed Central Ltd Critical Care 2008 12 201 doi cc6164 Abstract Sepsis still represents an important clinical and economic challenge for intensive care units. Severe complications like multiorgan failure with high mortality and the lack of specific diagnostic tools continue to hamper the development of improved therapies for sepsis. Fundamental questions regarding the cellular pathogenesis of experimental and clinical sepsis remain unresolved. According to experimental data inhibiting macrophage migration inhibitory factor high-mobility group box protein 1 HMGB1 and complement factor C5a and inhibiting the TREM-1 triggering receptor expressed on myeloid cells 1 signaling pathway and apoptosis represent promising new therapeutic options. In addition we have demonstrated that blocking the signal transduction pathway of receptor of advanced glycation endproducts RAGE a new inflammation-perpetuating receptor and a member of the immunglobulin superfamily increases survival in experimental sepsis. The activation of RAGE by advanced glycation endproducts S100 and HMGB1 initiates nuclear factor kappa B and mitogen-activated protein kinase pathways. Importantly the survival rate of RAGE knockout mice was more than fourfold that of wildtype mice in a .
