Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Intentional overdose with insulin: prognostic factors and toxicokinetic/toxicodynamic profiles. | Available online http content 11 5 R115 Research Intentional overdose with insulin prognostic factors and toxicokinetic toxicodynamic profiles Bruno Mégarbane1 Nicolas Deye2 Vanessa Bloch1 Romain Sonneville1 Corinne Collet2 Jean-Marie Launay2 and Frédéric J Baud1 Assistance Publique - Hôpitaux de Paris Hôpital Lariboisière Réanimation Médicale et Toxicologique INSERM U705 CNRS UMR 7157 Université Paris 7 Université Paris 5 2 Rue Ambroise Paré 75010 Paris France 2Assistance Publique - Hôpitaux de Paris Hôpital Lariboisière Laboratoire de Biochimie et de Biologie Moléculaire 2 Rue Ambroise Paré 75010 Paris France Corresponding author Bruno Mégarbane Received 31 Aug 2007 Revisions requested 28 Sep 2007 Accepted 28 Oct 2007 Published 28 Oct 2007 Critical Care 2007 11 R115 doi cc6168 This article is online at http content 11 5 R115 2007 Mégarbane et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Prognostic factors in intentional insulin selfpoisoning and the significance of plasma insulin levels are unclear. We therefore conducted this study to investigate prognostic factors in insulin poisoning in relation to the value of plasma insulin concentration. Methods We conducted a prospective study and used logistic regression to explore prognostic factors and modelling to investigate toxicokinetic toxicodynamic relationships. Results Twenty-five patients 14 female and 11 male median 25th to 75th percentiles age 46 36 to 58 years were included. On presentation the Glasgow Coma Scale score was 9 4 to 14 and the capillary glucose concentration was to mmol l. The plasma insulin concentration was 197 161 to 1 566 mIU l and the .
