Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: KL-6 in acute lung injury: will it leave its mark? | Available online http content 12 2 121 Commentary KL-6 in acute lung injury will it leave its mark Murali Shyamsundar1 and Danny F McAuley2 Research fellow Royal Victoria hospital Queen s University of Belfast Respiratory Research Group Microbiology Building Grosvenor Road Belfast BT12 6BA Senior lecturer Consultant intensive care physician Royal Victoria hospital Queen s University of Belfast Respiratory Research Group Microbiology Building Grosvenor Road Belfast BT12 6BA Corresponding author Danny McAuley Published 31 March 2008 This article is online at http content 12 2 121 2008 BioMed Central Ltd Critical Care 2008 12 121 doi cc6827 See related research by Nathani et al. http content 12 1 R12 Abstract Studies have indicated that measuring biochemical measures of epithelial injury in plasma and alveolar fluid may be useful in predicting outcome in acute lung injury. The present commentary briefly reviews the evidence supporting the use of these biochemical biomarkers of epithelial injury in acute lung injury and in particular KL-6 as well as their limitations. The article additionally proposes the need for physiological markers of epithelial function to complement current biochemical biomarkers. In the previous issue of Critical Care Nathani and colleagues have assessed KL-6 a specific marker of type 2 alveolar epithelial cell injury as a biomarker in acute lung injury ALI 1 . Biomarkers allow identification of patients at risk of developing disease or can be used as surrogate measures for clinical outcomes. Additionally measuring biological markers may be a valuable tool in understanding disease pathogenesis. In ALI the alveolar capillary barrier is disrupted and the alveolar epithelial cell function is critical to the recovery from ALI acute respiratory distress syndrome ARDS 2 . This knowledge provides a rationale for measurement of alveolar epithelial cell injury using surrogate biochemical .
