Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. | Available online http content 1 2 2 R41 Open Access Research Biomarkers of inflammation coagulation and fibrinolysis predict mortality in acute lung injury Dana McClintock1 Hanjing Zhuo1 Nancy Wickersham2 Michael A Matthay1 and Lorraine B Ware2 Cardiovascular Research Institute 505 Parnassus Avenue University of California San Francisco San Francisco CA 94143 USA 2Division of Allergy Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University T1218 MCN 1161 21st Avenue S Nashville TN 37232-2650 uSa Corresponding author Lorraine B Ware Received 17 Oct 2007 Revisions requested 22 Nov 2007 Revisions received 29 Jan 2008 Accepted 21 Mar 2008 Published 21 Mar 2008 Critical Care 2008 12 R41 doi cc6846 This article is online at http content 12 2 R41 2008 McClintock et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Acute lung injury ALI is a major cause of acute respiratory failure with high mortality despite lung-protective ventilation. Prior work has shown disordered inflammation and coagulation in ALI with strong correlations between biomarker abnormalities and worse clinical outcomes. We measured plasma markers of inflammation coagulation and fibrinolysis simultaneously to assess whether these markers remain predictive in the era of lung-protective ventilation. Methods Plasma samples and ventilator data were prospectively collected from 50 patients with early ALI. Plasma biomarkers of inflammation IL-6 IL-8 intercellular adhesion molecule 1 of coagulation thrombomodulin protein C and of fibrinolysis plasminogen activator inhibitor 1 were measured by ELISA. Biomarker levels were compared between survivors n 29 and .
