Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission. | Retrovirology BioMed Central Research Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission Rajesh Ramakrishnan1 2 Roshni Mehta1 Vasudha Sundaravaradan1 Tiffany Davis1 and Nafees Ahmad 1 Open Access Address Department of Microbiology and Immunology College of Medicine The University of Arizona Health Sciences Center Tucson Arizona 85724 USA and 2Current Address Department of Molecular Virology and Microbiology Baylor College of Medicine Houston Texas 77030 USA Email Rajesh Ramakrishnan - ramakris@ Roshni Mehta - roshnim@ Vasudha Sundaravaradan - vasudha@ Tiffany Davis - tadavis@ Nafees Ahmad - nafees@ Corresponding author Published 04 July 2006 Received 05 June 2006 Retrovirology 2006 3 42 doi 1742-4690-3-42 Accepted 04 July 2006 This article is available from http content 3 1 42 2006 Ramakrishnan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background HIV-1 envelope gp41 is a transmembrane protein that promotes fusion of the virus with the plasma membrane of the host cells required for virus entry. In addition gp41 is an important target for the immune response and development of antiviral and vaccine strategies especially when targeting the highly variable envelope gp120 has not met with resounding success. Mutations in gp4 1 may affect HIV-1 entry replication pathogenesis and transmission. We therefore characterized the molecular properties of gp41 including genetic diversity functional motifs and evolutionary dynamics from five mother-infant pairs following perinatal transmission. Results The gp41 open reading frame ORF was maintained with
