Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants. | Retrovirology BioMed Central Research Candidate polyanion microbicides inhibit HIV-I infection and dissemination pathways in human cervical explants Patricia S Fletcher Gregory S Wallace Pedro MM Mesquita and Robin J Shattock Open Access Address Centre for Infection Department of Cellular and Molecular Medicine St George s University of London London UK Email Patricia S Fletcher - pfletche@ Gregory S Wallace - gwallace@ Pedro MM Mesquita - pmesquit@ Robin J Shattock - shattock@ Corresponding author Published 01 August 2006 Received 18 January 2006 Accepted 01 August 2006 Retrovirology 2006 3 46 doi l 742-4690-3-46 This article is available from http content 3 1 46 2006 Fletcher et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Heterosexual intercourse remains the major route of HIV-1 transmission worldwide with almost 5 million new infections occurring each year. Women increasingly bear a disproportionate burden of the pandemic thus there is an urgent need to develop new strategies to reduce HIV-1 transmission that could be controlled by women themselves. The potential of topical microbicides to reduce HIV transmission across mucosal surfaces has been clearly identified and some agents are currently under evaluation in clinical trials. Many of these first generation microbicides consist of polyanionic compounds designed to interfere with viral attachment. Here we have evaluated two candidate polyanion compounds in clinical trials PRO 2000 and dextrin sulphate DxS to determine their safety and efficacy against in vitro HIV-1 and HSV-2 infection using .
