Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " The conserved dileucine- and tyrosine-based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking. | Retrovirology BioMed Central Research Open Access The conserved dileucine- and tyrosine-based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking Vincent Blot 11 3 4 5 6 Sandra Lopez-Vergèst2 3 4 5 Marie Breton1 3 4 5 Claudine Pique1 3 4 5 Clarisse Berlioz-Torrent2 3 4 5 and Marie-Pierre Grange1 3 4 5 Address 1Institut Cochin DépartementBiologie Cellulaire PariS F-75014 France 2Institut Cochin DépartementMaladies InfectieuseS PariS F-75014 France 3Inserm U567 Paris F-75014 France 4CNRS UMR 8104 Paris F-75014 France 5Université Paris 5 Faculté de Médecine René Descartes UMR3 Paris F-75014 France and 6Weill Medical College of Cornell Biochemistry Dept New York NY10021 USA Email Vincent Blot - Sandra Lopez-Vergès - slopez@ Marie Breton - breton@ Claudine Pique - pique@ Clarisse Berlioz-Torrent - berlioz@ Marie-Pierre Grange - marie- Corresponding author tEqual contributors Published 15 September 2006 Received 20 July 2006 Accepted 15 September 2006 Retrovirology 2006 3 62 doi l 742-4690-3-62 This article is available from http content 3 1 62 2006 Blot et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Retrovirus particles emerge from the assembly of two structural protein components Gag that is translated as a soluble protein in the cytoplasm of the host cells and Env a type I transmembrane protein. Because both components are translated in different intracellular compartments elucidating the mechanisms of retrovirus assembly thus requires the study of their intracellular trafficking. Results We .
