Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA. | Retrovirology BioMed Central Research PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA Cédric F Invernizzi1 BaodeXie1 Stéphane Richard2 and Mark A Wainberg 1 Open Access Address 1McGill University AIDS Centre Lady Davis Institute for Medical Research Sir Mortimer B. Davis Jewish General Hospital 3755 Côte-Ste-Catherine Rd Montréal Québec H3T 1E2 Canada and 2Terry Fox Molecular Oncology Group and Bloomfield Centre for Research on Aging Lady Davis Institute for Medical Research Sir Mortimer B. Davis Jewish General Hospital 3755 Côte-Ste-Catherine Rd Montréal Québec H3T 1E2 Canada Email Cédric F Invernizzi - Baode Xie - Stéphane Richard - Mark A Wainberg - Corresponding author Published 18 December 2006 Received 30 August 2006 _ . __ Accepted 18 December 2006 Retrovirology 2006 3 93 doi l 742-4690-3-93 This article is available from http content 3 1 93 2006 Invernizzi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The HIV-1 Rev protein mediates nuclear export of unspliced and partially spliced viral RNA through interaction with the Rev response element RRE by means of an arginine rich motif that is similar to the one found in Tat. Since Tat is known to be asymmetrically arginine dimethylated by protein arginine methyltransferase 6 PRMT6 in its arginine rich motif we investigated whether the Rev protein could act as a substrate for this enzyme. Results Here we report the methylation of Rev due to a single arginine dimethylation in the N-terminal
