Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein. | Retrovirology BioMed Central Research Open Access HIV-I integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein Maurizio Cianfriglia 11 Maria Luisa Dupuis11 Agnese Molinari1 Antonio Verdoliva2 Roberta Costi3 Clementina Maria Galluzzo1 Mauro Andreotti1 Andrea Cara1 Roberto Di Santo3 and Lucia Palmisano1 Address Department of Drug Research and Evaluation Istituto Superiore di Sanità Viale Regina Elena 299 00161 Rome Italy 2Tecnogen SCpA Piana di Monte Verna Caserta Italy and 3Istituto Pasteur-Fondazione Cenci Bolognetti Dipartimento Di Studi Farmaceutici Aldo Moro 5 00185 Rome Italy Email Maurizio Cianfriglia - Maria Luisa Dupuis - Agnese Molinari - Antonio Verdoliva - verdo@ Roberta Costi - Clementina Maria Galluzzo - Mauro Andreotti - Andrea Cara - Roberto Di Santo - Lucia Palmisano - Corresponding author fEqual contributors Published 7 March 2007 Received 27 November 2006 Accepted 7 March 2007 Retrovirology 2007 4 17 doi l 742-4690-4-17 This article is available from http content 4 1 17 2007 Cianfriglia et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The discovery of diketoacid-containing derivatives as inhibitors of HIV-1 Integrase IN IN inhibitors IINs has played a major role in validating this enzyme as an important target for antiretroviral therapy. Since the in vivo efficacy depends on access of these drugs to intracellular sites where HIV-1 replicates we determined whether the IINs are recognized by the .
