Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells. | Retrovirology BioMed Central Review Open Access Intracellular immunity to HIV-1 newly defined retroviral battles inside infected cells Yong-Hui Zheng and B Matija Peterlin Address Departments of Medicine Microbiology and Immunology Rosalind Russell Arthritis Research Center University of California San Francisco San Francisco CA 94143-0703 USA Email Yong-Hui Zheng - yonghui@ B Matija Peterlin - matija@ Corresponding authors Published 13 April 2005 Received 24 February 2005 Retrovirology 2005 2 25 doi 1742-4690-2-25 Accepted 13 April 2005 This article is available from http content 2 1 25 2005 Zheng and Peterlin licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Studies of the human immunodeficiency virus type 1 HIV-1 continue to enrich eukaryotic biology and immunology. Recent advances have defined factors that function after viral entry and prevent the replication of proviruses in the infected cell. Some of these attack directly viral structures whereas others edit viral genetic material during reverse transcription. Together they provide strong and immediate intracellular immunity against incoming pathogens. These processes also offer a tantalizing glimpse at basic cellular mechanisms that might restrict the movement of mobile genetic elements and protect the genome. Background Although it is highly pathogenic in humans HIV-1 cannot replicate in most other species 1 . This tropism is determined primarily by whether host cells express the required cofactors. For example by lacking a functional receptor and appropriate transcriptional machinery mouse cells do not support infection by HIV-1. Thus the organism resists the pathogen via a cell-based incompatibility.
