Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:APOBEC3G & HTLV-1: Inhibition without deamination | Retrovirology BioMed Central Commentary APOBEC3G HTLV-1 Inhibition without deamination Klaus Strebel Open Access Address Laboratory of Molecular Microbiology Viral Biochemistry Section National Institute of Allergy and Infectious Diseases NIH Building 4 Room 310 4 Center Drive MSC 0460 Bethesda MD 20892-0460 USA Email Klaus Strebel - kstrebel@ Corresponding author Published 29 May 2005 Received 18 May 2005 Retrovirology 2005 2 37 doi 1742-4690-2-37 Accepted 29 May 2005 This article is available from http content 2 1 37 2005 Strebel licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract APOBEC3G is a cellular cytidine deaminase that was recently identified as the Vif-sensitive antiviral host factor responsible for the restriction of vif-defective HIV-1 in primary human cells and certain non-permissive T cell lines. Inhibition of HIV-1 replication is thought to be the result of APOBEC3G-induced hypermutation of the viral genome that occurs early during reverse transcription. Against this backdrop is a new report from the Uchiyama laboratory that proposes deaminase-independent restriction of HTLV-1 by APOBEC3G Sasada et al. Retrovirology 2005 2 32 . These findings combined with recent reports of deaminase-independent inhibition of Hepatitis B virus as well as HIV-1 suggest that cytidine deaminase activity and antiviral activity may be separable functional properties of APOBEC3G. The identification of APOBEC3G APO3G in 2002 as the long elusive cellular target of the HIV viral infectivity factor Vif 1 has triggered an outburst of research activity that has produced in a short period of time a rather comprehensive working model for APO3G function Fig. 1 . Although the details of this .
