Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:" Evolution of subtype C HIV-1 Env in a slowly progressing Zambian infant | Retrovirology BioMed Central Research Open Access Evolution of subtype C HIV-1 Env in a slowly progressing Zambian infant Hong Zhang1 2 Federico Hoffmann2 Jun He1 2 Xiang He1 2 Chipepo Kankasa3 Ruth Ruprecht4 John T West1 2 Guillermo Orti2 and Charles Wood 1 2 Address 1Nebraska Center for Virology University of Nebraska Lincoln NE USA 2The School of Biological Sciences University of Nebraska Lincoln NE USA 3Department of Pediatrics University Teaching Hospital Lusaka Zambia and 4Dana-Farber Cancer Institute Harvard Medical School Boston MA USA Email HongZhang - hongz@ Federico Hoffmann - federicoh@ Jun He - jhe1@ Xiang He - xhe@ Chipepo Kankasa - ckankasa@ Ruth Ruprecht - ruth_ruprecht@ JohnT West - jwest2@ Guillermo Orti - gorti@ CharlesWood - cwood1@ Corresponding author Published 07 November 2005 Received 30 June 2005 Accepted 07 November 2005 Retrovirology 2005 2 67 doi 1742-4690-2-67 H This article is available from http content 2 1 67 2005 Zhang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Given the high prevalence of mother to child infection the development of a better understanding of African subtype C HIV-1 transmission and natural evolution is of significant importance. In this study we genotypically and phenotypically characterized subtype C viruses isolated over a 67-month follow-up period from an in utero-infected Zambian infant. Changes in genotype and phenotype were correlated to alterations of the host humoral immune response. Results A comparison of baseline maternal and infant samples indicated that the infant sequences are monophyletic and contain
