Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Patterns of evolution of host proteins involved in retroviral pathogenesis | Retrovirology BioMed Central Short report Open Access Patterns of evolution of host proteins involved in retroviral pathogenesis Millan Ortiz1 Gabriela Bleiber1 Raquel Martinez1 Henrik Kaessmann 2 and Amalio Telenti 1 Address institute of Microbiology and University Hospital University of Lausanne Switzerland and 2Center for Integrative Genomics University of Lausanne Lausanne Switzerland Email Millan Ortiz - Gabriela Bleiber - Raquel Martinez - Henrik Kaessmann - Amalio Telenti - Corresponding authors Published 07 February 2006 Received 23 December 2005 Accepted 07 February 2006 Retrovirology2006 3 11 doi 1742-4690-3-1 1 This article is available from http content 3 1 11 2006Ortiz et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Evolutionary analysis may serve as a useful approach to identify and characterize host defense and viral proteins involved in genetic conflicts. We analyzed patterns of coding sequence evolution of genes with known TRIM5a and APOBEC3G or suspected TRIMI9 PML roles in virus restriction or in viral pathogenesis PPIA encoding Cyclophilin A in the same set of human and non-human primate species. Results and conclusion This analysis revealed previously unidentified clusters of positively selected sites in APOBEC3G and TRIM5a that may delineate new virus-interaction domains. In contrast our evolutionary analyses suggest that PPIA is not under diversifying selection in primates consistent with the interaction of Cyclophilin A being limited to the HIV-1M SIVcpz lineage. The strong sequence conservation of the TRIMI9 PML .
