Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Functional analysis of human T lymphotropic virus type 2 Tax proteins | Retrovirology BioMed Central Research Open Access Functional analysis of human T lymphotropic virus type 2 Tax proteins Noreen Sheehy1 Lorraine Lillis1 Karen Watters1 Martha Lewis2 Virginie Gautier1 and William Hall 1 Address 1Centre for Research in Infectious Disease School of Medicine Medical Science University College Dublin Belfield Dublin 4 Ireland and 2University of California Department of Medicine UCLA Centre for Health Sciences Los Angeles California USA Email Noreen Sheehy - Lorraine Lillis - KarenWatters - Martha Lewis - MaLewis@ Virginie Gautier - William Hall - Corresponding author Published 21 March 2006 Received 24 October 2005 Accepted 21 March 2006 Retrovirology2006 3 20 doi 1742-4690-3-20 This article is available from http content 3 1 20 2006Sheehy et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The Tax proteins encoded by human T lymphotropic virus type 1 HTLV-1 and type 2 HTLV-2 are transcriptional activators of both the viral long terminal repeat LTR and cellular promoters via the CREB and NFkB pathways. In contrast to HTLV-1 HTLV-2 has been classified into four distinct genetic subtypes A B C and D defined by phylogenetic analysis of their nucleotide sequences and the size and amino acid sequence of their Tax proteins. In the present study we have analysed and compared the transactivating activities of three Tax 2A and one Tax 2B proteins using LTR and NFkB reporter assays. Results We found that with the exception of the prototype Tax 2A Mo protein the other two Tax 2A proteins failed to transactivate either the viral LTR or
