Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Mechanical induction of cough in Idiopathic Pulmonary Fibrosis. | Jones et al. Cough 2011 7 2 http content 7 1 2 Cough RESEARCH Open Access Mechanical induction of cough in Idiopathic Pulmonary Fibrosis 1 2 3 14 Richard M Jones 1 Simon Hilldrup Benjamin DM Hope-Gill Ronald Eccles and Nicholas K Harrison 1 Abstract Background Patients with idiopathic pulmonary fibrosis IPF frequently develop a dry irritating cough which often proves refractory to anti-tussive therapies. The precise pathogenetic mechanisms responsible for this cough are unknown. We hypothesised that changes in nerves modulating mechanical sensitivity in areas of interstitial fibrosis might lead to enhanced cough response to mechanical stimulation of the chest in IPF. Methods We studied 27 non-smoking subjects with IPF 63 male mean SD age 7 years and 30 healthy non-smokers. Quality of life Leicester Cough Questionnaire cough symptom scores and cough severity scores visual analog scales were recorded. Percussion stimulation was applied over the posterior lung base upper anterior chest and manubrium sternum at sequential frequencies 20 Hertz Hz 40 Hz and 60 Hz for up to 60 seconds and repeated twice at two minute intervals. The number of subjects achieving two and five-cough responses total cough counts and cough latency were recorded. In separate experiments the effect of mechanical stimulation on the pattern of breathing was determined in eight IPF subjects and five control subjects. Results In patients with IPF we demonstrated strong correlations between subjective cough measurements particularly the cough symptom score and Leicester Cough Questionnaire r p . Mechanical percussion induced a true cough reflex in 23 27 85 IPF subjects but only 5 30 17 controls p . More patients with IPF reached the two-cough response at a lower frequency 20 Hz posteriorly than at other positions. Highest mean cough totals were seen with stimulation at or above 40 Hz. Mechanical stimulation had no effect on respiratory rate but increased
