Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Single-drug therapy or selective decontamination of the digestive tract as antifungal prophylaxis in critically ill patients: a systematic review. | Available online http content 11 6 R126 Research Single-drug therapy or selective decontamination of the digestive tract as antifungal prophylaxis in critically ill patients a systematic review JW Olivier van Till1 Oddeke van Ruler1 Bas Lamme1 Roy JP Weber1 Johannes B Reitsma2 and Marja A Boermeester1 1 Department of Surgery Academic Medical Center . Box 22660 1100 DD Amsterdam The Netherlands 2Department of Clinical Epidemiology Biostatistics and Bioinformatics Academic Medical Center Room J1b-208 Meibergdreef 9 1105 AZ Amsterdam the Netherlands Corresponding author Marja A Boermeester Received 26 Jun 2007 Revisions requested 2 Aug 2007 Revisions received 16 Aug 2007 Published 7 Dec 2007 Critical Care 2007 11 R126 doi cc6191 This article is online at http content 11 6 R1 26 2007 van Till et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The objective of this study was to determine and compare the effectiveness of different prophylactic antifungal therapies in critically ill patients on the incidence of yeast colonisation infection candidemia and hospital mortality. Methods A systematic review was conducted of prospective trials including adult non-neutropenic patients comparing single-drug antifungal prophylaxis SAP or selective decontamination of the digestive tract SDD with controls and with each other. Results Thirty-three studies were included 11 SAP and 22 SDD 5 529 patients . Compared with control groups both SAP and SDD reduced the incidence of yeast colonisation SAP odds ratio OR 95 confidence interval CI to SDD OR 95 CI to and infection SAP OR 95 CI to SDD OR 95 CI
