Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Copeptin: a new and promising diagnostic and prognostic marker. | Available online http content 12 2 117 Commentary Copeptin a new and promising diagnostic and prognostic marker Mira Katan Beat Muller and Mirjam Christ-Crain Department of Endocrinology University Hospital Basel Petersgraben 4 CH-4031 Basel Switzerland Corresponding author Mirjam Christ-Crain Published 6 March 2008 This article is online at http content 12 2 117 2008 BioMed Central Ltd Critical Care 2008 12 117 doi cc6799 See related research by Seligman et al. http content 12 1 R11 Abstract The study conducted by Seligman and coworkers included in the previous issue of Critical Care demonstrates that copeptin is a promising marker to predict outcome in patients with ventilator-associated pneumonia. In recent years copeptin has emerged as a new prognostic marker in a variety of diseases such as sepsis community-acquired pneumonia chronic obstructive pulmonary failure heart failure and myocardial infarction. What is the pathophysiological basis for these findings Copeptin together with vasopressin is co- secreted from the posterior pituitary and therefore mirrors the amount of vasopressin in the circulation. Vasopressin is a main secretagogue of the hypothalamo-pituitary-adrenal axis thereby mirroring the individual stress level. Furthermore vasopressin is an important hormone in salt and volume regulation. In this context copeptin is also a diagnostic marker in patients with diabetes insipidus and in patients with disordered water states. In the previous issue of Critical Care Seligman and coworkers showed that copeptin the C-terminal part of the vasopressin prohormone increased continuously with the severity of sepsis 1 . Copeptin remained the only accurate prognostic marker for mortality in patients with ventilator-associated pneumonia. Procalcitonin and the PaO2 FiO2 ratio shown to be prognostic in ventilator-associated pneumonia 2 unfortunately were not included in the analysis. .
