Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo. | Available online http content 1 2 1 R27 Research Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo Stephanie Nonas1 Anna A Birukova2 Panfeng Fu2 Jungjie Xing2 Santipongse Chatchavalvanich2 Valery N Bochkov3 Norbert Leitinger4 Joe GN Garcia2 and Konstantin G Birukov2 Division of Pulmonary and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD 21224 USA 2Department of Medicine University of Chicago 5801 South Ellis St Chicago IL 60637 USA 3Department of Vascular Biology and Thrombosis Research Medical University of Vienna Schwarzspanierstrasse 1 7 1090 Vienna Austria 4Cardiovascular Research Center University of Virginia 415 Lane Rd Charlottesville VA 22908 USA Corresponding author Konstantin G Birukov kbirukov@ Received 7 Aug 2007 Revisions requested 13 Sep 2007 Revisions received 3 Jan 2008 Accepted 24 Jan 2008 Published 24 Jan 2008 Critical Care 2008 12 R27 doi cc6805 This article is online at http content 12 1 R27 2008 Nonas et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Background Mechanical ventilation at high tidal volume HTV may cause pulmonary capillary leakage and acute lung inflammation resulting in ventilator-induced lung injury. Besides blunting the Toll-like receptor-4-induced inflammatory cascade and lung dysfunction in a model of lipopolysaccharide-induced lung injury oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine OxPAPC exerts direct barrier-protective effects on pulmonary endothelial cells in vitro via activation of the small GTPases Rac and Cdc42. To test the hypothesis that OxPAPC may attenuate lung inflammation and barrier disruption .
