Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Improving survival by increasing lung edema clearance: is airspace delivery of dopamine a solution? | Available online http content 12 2 135 Commentary Improving survival by increasing lung edema clearance is airspace delivery of dopamine a solution Ariel Jaitovich and Jacob lasha Sznajder Division of Pulmonary and Critical Care Medicine Feinberg School of Medicine Northwestern University Chicago Illinois USA Corresponding author Jacob I Sznajder j-sznajder@ Published 15 April 2008 This article is online at http content 12 2 135 2008 BioMed Central Ltd Critical Care 2008 12 135 doi cc6825 See related research by Chamorro-Marin et al. http content 12 2 R39 Abstract In this issue of Critical Care Chamorro-Marin and coworkers provide new evidence that dopamine instilled into airspaces is beneficial in a rat model of ventilator-induced lung injury. This study is important because it is the first to explore the effects of dopamine on survival albeit short term. The delivery of dopamine into the airspaces in vivo is also novel and builds upon previous studies describing the mechanisms by which dopamine exerts its effect by upregulating active Na transport in the lungs. Dopamine appears to increase active Na transport via activation of amiloride-sensitive sodium channels and the basolateral Na K -ATPase within minutes and it has been shown to be effective in normal lungs and several models of lung injury. This information is relevant to current clinical trials exploring the effects of alveolar fluid clearance stimulation in patients with acute lung injury. In this issue of Critical Care Chamorro-Marin and coworkers 1 reported a significant decrease in short-term ventilator-induced lung injury VILI -related mortality by intratracheal administration of dopamine in rats subjected to injurious high tidal volume mechanical ventilation. This finding is interesting and has potentially relevant implications for mechanically ventilated patients with acute lung injury. VILI occurs when the lung tissue is disrupted by high
