Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The inflammation–coagulation axis as an important intermediate pathway in acute lung injury. | Available online http content 12 2 144 Commentary The inflammation-coagulation axis as an important intermediate pathway in acute lung injury Marcel Levi1 and Marcus Schultz2 1 Department of Vascular Medicine Internal Medicine F-4 Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam the Netherlands 2Department of Intensive Care Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam the Netherlands Corresponding author Marcel Levi Published 30 April 2008 This article is online at http content 12 2 144 2008 BioMed Central Ltd Critical Care 2008 12 144 doi cc6866 See related research by McClintock et al. http content 12 2 R41 Abstract Markers of inflammation coagulation and fibrinolysis predict an adverse outcome in patients with sepsis. These markers also seem predictive of an adverse outcome in patients with localized infection and inflammation such as in acute lung injury. Whether this is entirely related to the disease or is also due to ventilation strategies that may be harmful for the lungs however is not clear. In the present issue of Critical Care McClintock and colleagues demonstrate that these biomarkers retain their predictive effect even if lung-protective ventilation strategies are applied. Besides being biomarkers that predict outcome in patients with acute lung injury their activation of inflammation and coagulation seems also to play a pivotal role in the pathogenesis of acute lung injury and may thereby represent an interesting novel target for therapeutic intervention. In this issue of Critical Care McClintock and colleagues have studied markers of inflammation coagulation and fibrinolysis in critically ill patients with acute lung injury 1 . Severe infection and the consequent systemic inflammation are associated with significant morbidity and mortality. Risk stratification of patients upon admission to the emergency room or the .
