Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/: a microvascular perspective. | Available online http content 1 2 2 R54 Research Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130 a microvascular perspective Judith Martini1 Pedro Cabrales2 Ananda K3 Seetharama A Acharya3 Marcos Intaglietta1 and Amy G Tsai1 2 Department of Bioengineering University of California San Diego Gilman Dr La Jolla California 92093 USA 2La Jolla Bioengineering Institute Coast Blvd South La Jolla California 92037 USA department of Hematology and Medicine Albert Einstein College of Medicine Morris Park Avenue Bronx New York 10461 USA Corresponding author Amy G Tsai agtsai@ Received 25 Jan 2008 Revisions requested 25 Feb 2008 Revisions received 14 Mar 2008 Accepted 18 Apr 2008 Published 18 Apr 2008 Critical Care 2008 12 R54 doi cc6874 This article is online at http content 12 2 R54 2008 Martini et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Preoperative hemodilution is an established practice that is applied to reduce surgical blood loss. It has been proposed that polyethylene glycol PEG surface decorated proteins such as PEG-conjugated human serum albumin may be used as non-oxygen-carrying plasma expanders. The purpose of this study was to determine whether there is any difference in survival time after severe hemorrhagic shock following extreme hemodilution using a conventional hydroxyethyl starch HES -based plasma expander or PEG-albumin. Methods Experiments were performed using the hamster skinfold window preparation. Human serum albumin that was surface decorated with PEG was compared with Voluven 6 Fresenius Kabi Austria a starch solution that is of
