Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The promise of next generation colloids. | Available online http content 12 3 147 Commentary The promise of next generation colloids Ben C Creagh-Brown and Timothy W Evans Department of Critical Care Imperial College School of Medicine Royal Brompton Hospital Sydney Street London SW3 6NP UK Corresponding author Timothy W Evans Published 14 May 2008 Critical Care 2008 12 147 doi cc6892 This article is online at http content 12 3 147 2008 BioMed Central Ltd See related research by Martini et al. http content 12 2 R54 Abstract The aim of perioperative haemodilution is to reduce loss of red blood cells during elective surgery. The oncotic and molecular characteristics of the various plasma substitutes employed determine how effectively normovolaemia is maintained and their non-oncotic effects include alterations in microvascular perfusion. In the previous issue of Critical Care Martini and colleagues assessed the effects of haemodilution with either polyethylene glycol PEG ylated albumin or a commercially available hydroxyethyl starch-based colloid in a hamster haemorrhage model. PEGylated albumin was superior to hydroxyethyl starch as reflected by survival haemodynamic parameters and assessment of the microcirculation using intravital microscopy. In the previous issue of Critical Care Martini and colleagues 1 assessed the effects of haemodilution with either polyethylene glycol PEG ylated albumin or a commercially available hydroxyethyl starch-based colloid in a hamster haemorrhage model. The aim of perioperative haemodilution also termed acute normovolaemic hemodilution ANH is to reduce loss of red blood cells during elective surgery. It involves the collection of several units of blood from the patient before the operation and substitution of an equivalent volume of plasma expander. Although surgical blood loss remains unchanged the lost blood contains relatively fewer red blood cells and clotting factors. The patient s blood is returned to them
