Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients. | Available online http content 1 2 3 R70 Research Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients Marjolein de Wit1 Chris Gennings2 Wendy I Jenvey1 and Scott K Epstein3 Pulmonary and Critical Care Division Department of Internal Medicine School of Medicine Virginia Commonwealth University PO Box 980050 Richmond VA 23298-0050 USA 2Department of Biostatistics School of Medicine Virginia Commonwealth University Box 980032 Richmond VA USA 3Tufts University School of Medicine 145 Harrison Street Boston MA 02111 USA Corresponding author Marjolein de Wit mdewit@ Received 1 May 2008 Revisions requested 6 May 2008 Revisions received 13 May 2008 Accepted 20 May 2008 Published 20 May 2008 Critical Care 2008 12 R70 doi cc6908 This article is online at http content 12 3 R70 2008 de Wit et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Daily interruption of sedation DIS and sedation algorithms SAs have been shown to decrease mechanical ventilation MV duration. We conducted a randomized study comparing these strategies. Methods Mechanically ventilated adults 18 years old or older in the medical intensive care unit ICU were randomly assigned to DIS or SA. Exclusion criteria were severe neurocognitive dysfunction administration of neuromuscular blockers and tracheostomy. Study endpoints were total MV duration and 28day ventilator-free survival. Results The study was terminated prematurely after 74 patients were enrolled DIS 36 and SA 38 . The two groups had similar age gender racial distribution Acute Physiology and Chronic Health Evaluation II score and reason for MV.
