Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm. | Available online http content 1 2 5 R116 Open Access Research Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm Emmanuel Futier1 Jean-Michel Constantin1 Lydie Combaret2 Laurent Mosoni2 Laurence Roszyk3 Vincent Sapin3 Didier Attaix2 Boris Jung4 Samir Jaber4 and Jean-Etienne Bazin1 General Intensive Care Unit Hotel-Dieu Hospital University Hospital of Clermont-Ferrand Boulevard L. Malfreyt Clermond-Ferrand 63058 France 2Human Nutrition Research Center of Clermont-Ferrand Nutrition and Protein Metabolism Unit Institut National de la Recherche Agronomique Route de Theix Ceyrat 63122 France 3Department of Biochemistry University Hospital of Clermont-Ferrand Boulevard L. Malfreyt Clermont-Ferrand 63000 France 4SAR B Saint-Eloi Hospital University Hospital of Montpellier Avenue Augustin Fliche Montpellier 34000 France Corresponding author Jean-Michel Constantin jmconstantin@ Received 25 May 2008 Revisions requested 19 Jun 2008 Revisions received 31 Jul 2008 Accepted 11 Sep 2008 Published 11 Sep 2008 Critical Care 2008 12 R116 doi cc7010 This article is online at http content 12 5 R116 2008 Futier et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Controlled mechanical ventilation CMV induces profound modifications of diaphragm protein metabolism including muscle atrophy and severe ventilator-induced diaphragmatic dysfunction. Diaphragmatic modifications could be decreased by spontaneous breathing. We hypothesized that mechanical ventilation in pressure support ventilation PSV which preserves diaphragm muscle activity would limit diaphragmatic protein catabolism. Methods Forty-two adult Sprague-Dawley rats
