Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury. | Available online http content 1 2 5 R131 Research Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury Sebastien Trachsel1 2 Ginette Deby-Dupont3 4 Edwige Maurenbrecher1 Monique Nys3 4 Maurice Lamy3 4 and Goran Hedenstierna1 Department of Medical Sciences Clinical Physiology Uppsala University S-751 85 Uppsala Sweden 2Department of Anesthesiology University Hospital Inselspital Bern CH-3010 Bern Switzerland 3Department of Anaesthesia and Intensive Care Medicine University Hospital of Liège Domaine du Sart Tilman - B35 B-4000 Liège Belgium 4Centre for Oxygen Research and Development Institute of Chemistry B6a University of Liège Sart Tilman Belgium University of Liège B-4000 Liege Belgium Corresponding author Goran Hedenstierna Received 25 Jul 2008 Revisions requested 21 Aug 2008 Revisions received 16 Sep 2008 Accepted 27 Oct 2008 Published 27 Oct 2008 Critical Care 2008 12 R131 doi cc7099 This article is online at http content 12 5 R131 2008 Trachsel et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Inhaled nitric oxide INO allows selective pulmonary vasodilation in acute respiratory distress syndrome and improves PaO2 by redistribution of pulmonary blood flow towards better ventilated parenchyma. One-third of patients are nonresponders to INO however and it is difficult to predict who will respond. The aim of the present study was to identify within a panel of inflammatory mediators released during endotoxin-induced lung injury specific mediators that are associated with a PaO2 response to INO. Methods After animal ethics committee approval pigs were
