Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Determinants and impact of multidrug antibiotic resistance in pathogens causing ventilator-associated-pneumonia. | Available online http content 1 2 6 R142 Research Determinants and impact of multidrug antibiotic resistance in pathogens causing ventilator-associated-pneumonia Pieter O Depuydt1 Dominique M Vandijck1 Maarten A Bekaert2 Johan M Decruyenaere1 Stijn I Blot3 Dirk P Vogelaers3 and Dominique D Benoit1 Department of Intensive Care Ghent University Hospital De Pintelaan 185 B-9000 Gent Belgium 2Department of Applied Mathematics and Computer Science Ghent University Krijgslaan 281 S9 B-9000 Gent Belgium 3Department of Internal Medicine and Infectious Diseases Ghent University Hospital De Pintelaan 185 B-9000 Gent Belgium Corresponding author Pieter O Depuydt Received 15 May 2008 Revisions requested 15 Jun 2008 Revisions received 14 Oct 2008 Accepted 17 Nov 2008 Published 17 Nov 2008 Critical Care 2008 12 R142 doi cc7119 This article is online at http content 12 6 R1 42 2008 Depuydt et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The idea that multidrug resistance MDR to antibiotics in pathogens causing ventilator-associated pneumonia VAP is an independent risk factor for adverse outcome is still debated. We aimed to identify the determinants of MDR versus non-MDR microbial aetiology in VAP and assessed whether MDR versus non-MDR VAP was independently associated with increased 30-day mortality. Methods We performed a retrospective analysis of a prospectively registered cohort of adult patients with microbiologically confirmed VAP diagnosed at a university hospital intensive care unit during a three-year period. Determinants of MDR as compared with non-MDR microbial aetiology and impact of MDR versus non-MDR aetiology on mortality were .
