Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Procalcitonin-guided antibiotics in severe sepsis. | Available online http content 1 2 6 309 Journal club critique Procalcitonin-guided antibiotics in severe sepsis Peter Simon1 Eric B Milbrandt2 and Lillian L Emlet2 Open Access Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2Assistant Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Corresponding author Peter Simon Published 4 Dec 2008 Critical Care 2008 12 309 doi cc7124 This article is online at http content 12 6 309 2008 BioMed Central Ltd Article details Evidence-Based Medicine Journal Club EBM Journal Club SectionEric B Milbrandt Expanded Abstract Citation Nobre V Harbarth S Graf JD Rohner P Pugin J Use of procalcitonin to shorten antibiotic treatment duration in septic patients a randomized trial. Am J Respir Crit Care Med 2008 177 498-505 1 . Background The duration of antibiotic therapy in critically ill patients with sepsis can result in antibiotic overuse increasing the risk of developing bacterial resistance. Procalcitonin PCT -guided antibiotic use reduces antibiotic exposure in community-acquired pneumonia. Whether it might also reduce antibiotic exposure in severe sepsis is unknown. Methods Objective To test the hypothesis that an algorithm based on serial measurements of PCT allows reduction in the duration of antibiotic therapy compared with empirical rules and does not result in more adverse outcomes in patients with severe sepsis and septic shock. Design Single-center non-blinded randomized controlled trial. Setting Mixed medical and surgical ICU at a university teaching hospital. Subjects 79 adult patients with suspected severe sepsis or septic shock. Intervention All patients had circulating PCT levels drawn daily. In patients randomly assigned to the intervention group antibiotics were stopped when PCT levels had decreased 90 or more from the initial value if .
