Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:The effect of antimicrobial resistance on patient outcomes: importance of proper evaluation of appropriate therapy. | Available online http content 13 1 106 Commentary The effect of antimicrobial resistance on patient outcomes importance of proper evaluation of appropriate therapy Mitchell J Schwaber1 and Yehuda Carmeli2 1 National Center for Infection Control Israel Ministry of Health 6 Weizmann St. Tel Aviv 64239 Israel 2Department of Epidemiology and Preventive Medicine Tel Aviv Medical Center 6 Weizmann St. Tel Aviv 64239 Israel Corresponding author Mitchell J Schwaber mitchells@ Published 12 January 2009 This article is online at http content 13 1 106 2009 BioMed Central Ltd Critical Care 2009 13 106 doi cc7136 See related research by Depuydt et al. http content 12 6 R142 Abstract The impact of antimicrobial resistance on patient outcomes can be effectively measured only if the appropriateness of the antimicrobial therapy received is properly measured. Definition of appropriate therapy should include not only in vitro susceptibility but also the clinical adequacy of the antibiotic used taking into account the pathogen isolated the site of infection known pharmacokinetic and pharmacodynamic properties of the drug and dosing. In the absence of these data the effect of delay or absence of appropriate therapy in patients infected with resistant bacterial pathogens is subject to confounding and the true effect of resistance on outcomes may be obscured. Do infections with antibiotic-resistant pathogens yield worse outcomes than similar infections in similar patients with susceptible pathogens The practical importance of knowing the answer to this question relates both to infection control -that is are the considerable resources and inconveniences required to contain the spread of multi-drug-resistant MDR bacteria justified by reduced morbidity and mortality - and to treatment decisions - that is should empirical antimicrobial therapy be modified in the face of resistance A number of reasons that MDR pathogens may be .
