Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Excess circulating angiopoietin-2 levels in sepsis: harbinger of death in the intensive care unit? | Available online http content 13 1 114 Commentary Excess circulating angiopoietin-2 levels in sepsis harbinger of death in the intensive care unit John S Giuliano Jr1 and Derek S Wheeler2 1 Division of Critical Care Medicine Department of Pediatrics Yale University School of Medicine 333 Ceder St Yale-New Haven Children s Hospital West Pavilion 2nd floor New Haven CT 06510 USA 2Division of Critical Care Medicine Cincinnati Children s Hospital Medical Center Department of Pediatrics University of Cincinnati College of Medicine 3333 Burnet Avenue Cincinnati OH 45229-3039 USA Corresponding author Derek S Wheeler Published 27 January 2009 This article is online at http content 13 1 114 2009 BioMed Central Ltd Critical Care 2009 13 114 doi cc7685 See related research by Kumpers et al. http content 12 6 R147 Abstract The early recognition and management of sepsis remain the greatest challenges in the field of critical care medicine. Endothelial injury is one of the hallmarks of sepsis leading to capillary leak microcirculatory dysfunction organ failure and eventual death in many critically ill patients. The angiogenic growth factors angiopoietin angpt -1 and angpt-2 act upon the Tie-2 receptor in opposing roles. Angpt-2 has been found in abundance in septic patients when compared with healthy controls. In the study by Kumpers and colleagues in the previous issue of Critical Care angpt-2 levels correlated with markers of tissue hypoxia disease severity and mortality in septic adults. However the temporal kinetics of the angiopoietins were not assessed. It remains to be seen whether angpt-2 levels will function solely as an early marker of sepsis or whether the manipulation of the angpt Tie-2 system will become a rational therapeutic target for the management of sepsis. In the previous issue of Critical Care Kumpers and colleagues 1 demonstrated a direct correlation between increased peripheral blood .
