Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice. | Available online http content 13 1 R1 Research Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice Esther K Wolthuis1 2 3 Alexander PJ Vlaar1 3 Goda Choi3 4 Joris JTH Roelofs5 Nicole P Juffermans1 3 and Marcus J Schultz1 3 6 1 Department of Intensive Care Medicine University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam The Netherlands 2Department of Anesthesiology University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam The Netherlands laboratory of Experimental Intensive Care and Anesthesiology LEICA University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam The Netherlands Department of Internal Medicine University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam The Netherlands 5Department of Pathology University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam The Netherlands 6HERMES Critical Care Group Amsterdam The Netherlands Corresponding author Esther K Wolthuis Received 18 Sep 2008 Revisions requested 8 Oct 2008 Revisions received 19 Nov 2008 Accepted 19 Jan 2009 Published 19 Jan 2009 Critical Care 2009 13 R1 doi cc7688 This article is online at http content 13 1 R1 2009 Wolthuis et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Mechanical ventilation MV may cause ventilator-induced lung injury VILI . Present models of VILI use exceptionally large tidal volumes causing gross lung injury and haemodynamic shock. In addition animals are ventilated for a relative short period of time and only after a priming pulmonary insult. Finally it is uncertain whether metabolic acidosis which frequently develops in models of VILI should be prevented. To
