Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Within you, without you: HIV-1 Rev and RNA export | Retrovirology BioMed Central Commentary Within you without you HIV-1 Rev and RNA export Andrew I Dayton Address Center for Biologics Evaluation and Research Food and Drug Administration USA Email Andrew I Dayton - dayton@ Corresponding author Open Access Published 29 October 2004 Retrovirology 2004 1 35 doi l 742-4690-1-35 Received 28 October 2004 Accepted 29 October 2004 This article is available from http content 1 1 35 2004 Dayton licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Nucleo-cytoplasmic transport of RNA is one of many cellular pathways whose illumination has progressed hand in hand with understanding of retroviral mechanisms. A recent paper in Cell reports the involvement of an RNA helicase in the pathway by which HIV exports partially spliced and unspliced RNA out of the nucleus. This suggests the ubiquity of RNA helicases in RNA export from the nucleus and has novel mechanistic implications. HIV must export to the cytoplasm not only full length genomic and structural gene-encoding RNA species but also partially and fully spliced RNAs which code for a variety of overlapping structural and accessory genes. Whereas the fully spliced HIV RNA species readily exit the nucleus and undergo translation the partially spliced and unspliced species require the interaction of the HIV-1 Rev protein with the cis-acting viral RRE Rev responsive element for expression. Simpler retroviruses such as the type-D Mason-Pfizer monkey virus MPMV solve a similar problem by encoding a cis-acting constitutively active CTE constitutive transporter element in the 3 UTR of the viral genome which uses a distinct pathway 1 2 . Of less clear significance is the existence of CRM-1 dependent .
