Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication | Retrovirology BioMed Central Short report Open Access Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication Vyjayanthi Krishnan and Steven L Zeichner Address HIV and AIDS Malignancy Branch National Cancer Institute National Institutes of Health Building 10 Room 10S255 MSC1868 Bethesda MD 20892 USA Email Vyjayanthi Krishnan - vkrishna@ Steven LZeichner - zeichner@ Corresponding author Published 08 December 2004 Received 02 December 2004 Accepted 08 December 2004 Retrovirology 2004 1 42 doi 1742-4690-1-42 This article is available from http content 1 1 42 2004 Krishnan and Zeichner licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Recent results showed that certain DEAD box protein RNA helicases DDX3 and DDXI play an important role in the HIV infection cycle by facilitating the export of long singly spliced or unspliced HIV RNAs from the nucleus via the CRM 1-Rev pathway. Close examination of an extensive microarray expression profiling dataset obtained from cells latently infected with HIV induced to undergo lytic viral replication indicated that additional DEAD box proteins beyond DDX3 and DDX1 exhibit differential expression during lytic HIV replication and in latently infected cells prior to induction into active replication. This finding provides additional evidence that the involvement of DEAD box proteins and other RNA-binding proteins may play roles in active HIV replication and in the control of viral latency. Agents targeting these functions may offer new approaches to antiretroviral therapy and the therapeutic manipulation of HIV latency. Findings The DEAD box proteins a family of RNA helicases containing the .
