Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: HIV-1 Tat protein enhances Microtubule polymerization | Retrovirology BioMed Central Research HIV-1 Tat protein enhances Microtubule polymerization Jean de Mareuil Manon Carre Pascale Barbier Grant R Campbell Sophie Lancelot Sandrine Opi Didier Esquieu Jennifer D Watkins Charles Prevot Diane Braguer Vincent Peyrot and Erwann P Loret Open Access Address UMR Univ. Med. CNRS FRE 2737 Faculté de Pharmacie Université de la Méditerranée 27 Bd Jean Moulin 13385 Marseille France Email Jean de Mareuil - Manon Carre - manoncarre@ Pascale Barbier - Grant R Campbell - gcampbell@ Sophie Lancelot - sophielancelot@ Sandrine Opi - s_opi@ Didier Esquieu - desquieu@ Jennifer D Watkins - jwatkins@ Charles Prevot - cprevot@ Diane Braguer - Vincent Peyrot - Erwann P Loret - Corresponding author Published 03 February 2005 Retrovirology 2005 2 5 doi 1742-4690-2-5 Received 24 November 2004 Accepted 03 February 2005 This article is available from http content 2 1 5 2005 de Mareuil et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background HIV infection and progression to AIDS is characterized by the depletion of T cells which could be due in part to apoptosis mediated by the extra-cellular HIV-encoded Tat protein as a consequence of Tat binding to tubulin. Microtubules are tubulin polymers that are essential for cell structure and division. Molecules that target microtubules induce apoptosis and are potent anticancer drugs. We studied the effect on tubulin .
