Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment. | Comparative Hepatology BioMed Central Research Open Access Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia new models for clinical hepatocyte growth factor treatment Bart Spee 1 Louis C Penning1 Ted SGAM van den Ingh2 Brigitte Arends1 Jooske IJzer2 Frederik J van Sluijs1 and Jan Rothuizen1 Address Department of Clinical Sciences of Companion Animals Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands and 2Department of Pathobiology Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands Email Bart Spee - Louis C Penning - Ted SGAM van den Ingh - Brigitte Arends - Jooske IJzer - Frederik J van Sluijs - Jan Rothuizen - Corresponding author Published 07 December 2005 Received 10 February 2005 Accepted 07 December 2005 Comparative Hepatology 2005 4 7 doi 86 1476-5926-4-7 r This article is available from http content 4 1 7 2005 Spee et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We analyzed two spontaneous dog diseases characterized by subnormal portal perfusion and reduced liver growth i congenital portosystemic shunts CPSS without fibrosis and ii primary portal vein hypoplasia PPVH a disease associated with fibrosis. These pathologies that lack inflammation or cholestasis may represent simplified models to study liver growth and fibrosis. To investigate the possible use of those models for hepatocyte growth factor HGF treatment we studied the functionality of HGF signaling in CPSS and PPVH dogs and compared this to .
