Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A new parameter using serum lactate dehydrogenase and alanine aminotransferase level is useful for predicting the prognosis of patients at an early stage of acute liver injury: A retrospective study. | Comparative Hepatology BioMed Central Open Access A new parameter using serum lactate dehydrogenase and alanine aminotransferase level is useful for predicting the prognosis of patients at an early stage of acute liver injury A retrospective study Kazuhiro Kotoh Munechika Enjoji Masaki Kato Motoyuki Kohjima Makoto Nakamuta and Ryoichi Takayanagi Address Department of Medicine and Bioregulatory Science Graduate School of Medical Science Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan Email Kazuhiro Kotoh - kotoh-k@ Munechika Enjoji - enjoji@ Masaki Kato - mkato11@ Motoyuki Kohjima - kohjima@ Makoto Nakamuta - nakamuta@ Ryoichi Takayanagi - takayana@ Corresponding author Published 14 August 2008 Comparative Hepatology 2008 7 6 doi l476-5926-7-6 Received 27 December 2007 Accepted 14 August 2008 This article is available from http content 7 l 6 2008 Kotoh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Although most patients with severe acute hepatitis are conservatively cured some progress to acute liver failure ALF with a high rate of mortality. Based on the evidence that overactivation of macrophages followed by disturbance of the hepatic microcirculation plays a key role in ALF we hypothesized that the production of serum lactate dehydrogenase LDH might increase in the liver under hypoxic conditions and could be an indicator to discriminate between conservative survivors and fatal patients at an early stage. Results To confirm this hypothesis we .
