Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Low-dose, long-term macrolide therapy in asthma: An overview. | Clinical and Molecular Allergy BioMed Central Review Open Access Low-dose long-term macrolide therapy in asthma An overview Umur Hatipoglu and Israel Rubinstein Address Section of Respiratory and Critical Care Medicine Department of Medicine and Department of Biopharmaceutical Sciences Colleges of Medicine and Pharmacy University of Illinois at Chicago and VA Chicago Health Care System Chicago Illinois 60612 Email Umur Hatipoglu - ushatipo@ Israel Rubinstein - IRubinst@ Corresponding author Published 16 March 2004 Received 03 February 2004 Accepted 16 March 2004 Clinical and Molecular Allergy 2004 2 4 r This article is available from http content 2 l 4 2004 Hatipoglu and Rubinstein licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Macrolides a class of antimicrobials isolated from Streptomycetes more than 50 years ago are used extensively to treat sinopulmonary infections in humans. In addition a growing body of experimental and clinical evidence indicates that long-term years low sub-antimicrobial -dose l4- and l5-membered ring macrolide antibiotics such as erythromycin clarithromycin roxithromycin and azithromycin express immunomodulatory and tissue reparative effects that are distinct from their anti-infective properties. These salutary effects are operative in various lung disorders including diffuse panbronchiolitis cystic fibrosis persistent chronic rhinosinusitis nasal polyposis bronchiectasis asthma and cryptogenic organizing pneumonia. The purpose of this overview is to outline the immunomodulatory effects of macrolide antibiotics in patients with asthma. Macrolide antibiotics and asthma pathogenesis Asthma is a chronic inflammatory disease characterized by airway narrowing. There are three distinct components of .
