Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: CCR3, CCR5, CCR8 and CXCR3 expression in memory T helper cells from allergic rhinitis patients, asymptomatically sensitized and healthy individuals. | Clinical and Molecular Allergy BioMed Central Research Open Access CCR3 CCR5 CCR8 and CXCR3 expression in memory T helper cells from allergic rhinitis patients asymptomatically sensitized and healthy individuals Mille Holse Kristian Assing and Lars K Poulsen Address Laboratory for Medical Allergology 7542 National University Hospital Blegdamsvej 9 DK-2100 Copenhagen Denmark Email Mille Holse - mholse@ KristianAssing- Lars K Poulsen - lkpallgy@ Corresponding author Published 19 April 2006 Received 29 November 2005 -n J . . AH_ zvz A J_. IZX I ir z i A-7Z -7 zI zz Accepted 19 April 2006 Clinical and Molecular Allergy 2006 4 6 doi 1476-7961-4-6 This article is available from http content 4 1 6 2006 Holse et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Chemokine receptors have been suggested to be preferentially expressed on CD4 T cells with CCR3 and CCR8 linked to the T helper Th 2 subset and CCR5 and CXCR3 to the Th1 subset however this remains controversial. Objective Our aim was to compare the CCR3 CCR5 CCR8 and CXCR3 expression in memory Th cells from allergic asymptomatically sensitized and healthy individuals. Methods Peripheral blood mononuclear cells from 8 pollen allergic rhinitis patients 10 asymptomatically sensitized and 10 healthy individuals were stimulated for 7 days with allergen or tetanus toxoid. CCR3 CCR5 CCR8 CXCR3 CD4 and CD45RO were detected by flow cytometry. Results No differences in chemokine receptor expression were observed between the three groups on day 0 and seven days of unstimulated culture did not change the expression. Both antigenic stimuli increased the chemokine .
