Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Skin prick testing does not reflect the presence of IgE against food allergens in adult eosinophilic esophagitis patients: a case study. | Kamdar et al. Clinical and Molecular Allergy 2010 8 16 http content 8 1 16 CMA CLINICAL AND MOLECULAR ALLERGY CASE REPORT Open Access Skin prick testing does not reflect the presence of IgE against food allergens in adult eosinophilic esophagitis patients a case study Toral A Kamdar Anne M Ditto Paul J Bryce Abstract Skin prick testing is widely used to predict the presence of allergen-specific IgE. In eosinophilic esophagitis patients who frequently exhibit polysensitization and broad reactivity upon skin prick testing this is commonly used to aid avoidance recommendations in the clinical management of their disease. We present here the predictive value of skin prick testing for the presence of allergen-specific IgE in 12 patients determined by immunoblot against the allergen extracts using individual-matched serum. Our results demonstrate a high degree of predictive value for aeroallergens but a poor predictive value for food allergens. This suggests that skin prick testing likely identifies IgE reactivity towards aeroallergens in adult eosinophilic esophagitis but this is not true for foods. Consequently IgE immunoblotting might be required for determining food avoidance in these patients. Background Eosinophilic esophagitis EoE is a gastrointestinal disorder that is associated with allergic disease. Studies have described personal or family histories of asthma or allergic rhinitis in adult EoE patients 1 2 and a murine model has shown that aeroallergen sensitization may be responsible for the eosinophilic response in the esophagus 3 . Adult EoE patients display a broad range of reactivity to multiple allergens that spans both aero and food allergens. In one study 81 of EoE patients had poly-reactivity to environmental allergens on skin prick testing SPT 4 . In light of such broad reactivity we queried the reliability of SPT for determining actual IgE-mediated reactions in this patient population. Case Study Here we compared the
