Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Assessment of efficacy and impact on work productivity and attendance after a mandatory switch to generic second-generation antihistamines: results of a patient survey in Norway. | Thorn et al. Clinical and Molecular Allergy 2011 9 5 http content 9 1 5 RESEARCH CMA CLINICAL AND MOLECULAR ALLERGY Open Access Assessment of efficacy and impact on work productivity and attendance after a mandatory switch to generic second-generation antihistamines results of a patient survey in Norway 1 2 2 2 3 Fredrik Thorn Halvor Celius Tone 0degard Randeep Mandla Erik Hexeberg Abstract Background In 2006 the Norwegian Medicines Agency mandated a switch from desloratadine ebastine or fexofenadine to cetirizine or loratadine in patients with allergic rhinitis AR or chronic urticaria CU . In an online survey patients whose medication was switched assessed the impact on efficacy fatigue and work productivity attendance. Methods Allergy patients in Norway completed a 25-item online survey. Patients aged 18 years with AR or CU who were switched to cetirizine or loratadine from desloratadine ebastine or fexofenadine were included. Participants rated post-switch efficacy fatigue and effect on work productivity attendance compared with their pre-switch medication. Patients also reported post-switch change in number of doctor visits required total treatment cost and whether they had switched or wanted to switch back to their previous medications. Results Of 1920 patients invited 493 responded and 409 of these were eligible. Previous antihistamines were desloratadine of respondents ebastine and fexofenadine . Post-switch received cetirizine and loratadine. Compared with previous therapy cetirizine and loratadine were rated less effective by of respondents reported increased fatigue and reported decreased work productivity with the generic agents. At the time of the survey 26 of respondents had switched back to their previous medication. Conclusions This is the first survey to assess the impact on patient-reported outcomes of a mandated switch from prescription to generic antihistamines in Norway. The
