Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effects of Fructus Piperis Longi extract on fibrotic liver of gamma-irradiated rats. | Chinese Medicine BioMed Central Research Effects of Fructus Piperis Longi extract on fibrotic liver of gamma-irradiated rats Somaya Zakaria Mansour 1 and Hanan El-Kabany2 Open Access Address Radiation Biology Department National Centre for Radiation Research and Technology Atomic Authority Cairo Egypt and 2Health Radiation Research Department National Centre for Radiation Research and Technology Atomic Authority Cairo Egypt Email Somaya Zakaria Mansour - szmansour@ Hanan El-Kabany - moonyhabiby@ Corresponding author Published 30 January 2009 Received 7 April 2008 Accepted 30 January 2009 Chinese Medicine 2009 4 2 doi 1749-8546-4-2 This article is available from http content 4 1 2 2009 Mansour and El-Kabany licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A major biomarker for liver fibrosis is transglutaminase which catalyzes cross-linking of epsilon-amines and alpha-glutamyl residues among amino acids leading to fibrosis. Fructus Piperis Longi is a common herb used in Chinese medicine. The present study evaluates the role of the ethanol extract of Fructus Piperis Longi in the modulation of liver function in liver fibrosis. Methods Plf extract 50 mg kg was force-fed to rats every other day 7 days before administration of thioacetamide and or gamma irradiation. Thioacetamid 200 mg kg was intraperitoneally administered to rats twice per week for four weeks. Rats were gamma irradiated 2 Gy week up to a total dose of 8 Gy . Administration of Plf ext was extended during thioacetamid and or irradiation treatment. Animals were sacrificed. Biochemical parameters in homogenised liver were tested. Results A significant increase in transglutaminase activity and collagen
