Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts. | Kurian et al. Chinese Medicine 2010 5 3 http content 5 1 3 CHINESE MEDICINE RESEARCH Open Access Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts Gino A Kurian1 Srilalitha Suryanarayanan2 Archana Raman2 Jose Padikkala3 Abstract Background This study aims to evaluate the antioxidant potential of the ethyl acetate extract of Desmodium gangeticum root for cardioprotection from ischemia reperfusion-induced oxidative stress. Methods The in vitro antioxidant potential of the extract was in terms of hydroxyl radical scavenging activity lipid peroxide scavenging activity nitric oxide scavenging activity and diphenylpicrylhydrazyl radical scavenging activity. The in vivo antioxidant potential of the extract was assessed in an isolated rat heart model. Results Free radicals were scavenged by the extract in a concentration-dependent manner within the range of the given concentrations in all models. Administration of the ethyl acetate extract of Desmodium gangeticum root 100 mg per kg body weight before global ischemia caused a significant improvement of cardiac function and a decrease in the release of lactate dehydrogenase in coronary effluent as well as the level of malondialdehyde in myocardial tissues. Conclusion The ethyl acetate extract of Desmodium gangeticum root protects the myocardium against ischemiareperfusion-induced damage in rats. The effects of the extract may be related to the inhibition of lipid peroxidation. Background Many plants contain substantial amounts of antioxidants such as vitamins C and E carotenoids flavonoids and tannins that can be utilized to scavenge excess free radicals from the human body 1 . The free radical scavenging potential of natural antioxidants varies among diseases and types of antioxidant 2 . Antioxidants protect the human body against free radical attacks that may cause pathological conditions such as ischemia reperfusion 3 . .
