Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906. | Tilton et al. Chinese Medicine 2010 5 30 http content 5 1 30 CHINESE MEDICINE RESEARCH Open Access A comprehensive platform for quality control of botanical drugs PhytomicsQC a case study of Huangqin Tang HQT and PHY906 1 1 I- V 1 1 1 1 Robert Tilton Anthony A Paiva Jing-Qu Guan Rajendra Marathe Zaoli Jiang Winfried van Eyndhoven 1 1 1 1 z l z-l 2 Jeffrey Bjoraker Zachary Prusoff Hailong Wang Shwu-Huey Liu Yung-Chi Cheng Abstract Background Establishing botanical extracts as globally-accepted polychemical medicines and a new paradigm for disease treatment requires the development of high-level quality control metrics. Based on comprehensive chemical and biological fingerprints correlated with pharmacology we propose a general approach called PhytomicsQC to botanical quality control. Methods Incorporating the state-of-the-art analytical methodologies PhytomicsQC was employed in this study and included the use of liquid chromatography mass spectrometry LC MS for chemical characterization and chemical fingerprinting differential cellular gene expression for bioresponse fingerprinting and animal pharmacology for in vivo validation. A statistical pattern comparison method Phytomics Similarity Index PSI based on intensities and intensity ratios was used to determine the similarity of the chemical and bioresponse fingerprints among different manufactured batches. Results Eighteen batch samples of Huangqin Tang HQT and its pharmaceutical grade version PHY906 were analyzed using the PhytomicsQC platform analysis. Comparative analysis of the batch samples with a clinically tested standardized batch obtained values of PSI similarity between and . Conclusion With rigorous quality control using analytically sensitive and comprehensive chemical and biological fingerprinting botanical formulations manufactured under standardized manufacturing protocols can produce highly consistent batches of products. Background Quality control for herbal extracts .
