Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Local recurrence and assessment of sentinel lymph node biopsy in deep soft tissue leiomyosarcoma of the extremities. | Lamyman et al. Clinical Sarcoma Research 2011 1 7 http content 1 1 7 CLINICAL SARCOMA RESEARCH RESEARCH Open Access Local recurrence and assessment of sentinel lymph node biopsy in deep soft tissue leiomyosarcoma of the extremities Michael J Lamyman Henk P Giele Paul Critchley Duncan Whitwell Max Gibbons and Nicholas A Athanasou Abstract Background Leiomyosarcoma of deep soft tissues of the extremities is a rare malignant tumour treated primarily by surgery. The incidence of local recurrence and lymph node metastasis is uncertain and it is not known whether a sentinel lymph node biopsy is indicated in these tumours. Methods A retrospective review of patients treated for extremity deep soft tissue leiomyosarcoma at our institution over a 10-year period was conducted. Patients developing local recurrence or lymph node metastasis were identified. The presence or absence of lymphatics in the primary tumours was assessed by immunohistochemical expression of LYVE-1 and podoplanin. Results 27 patients mean age 62 years were included in the study. 15 were female and 12 male. Lymph node metastasis was seen in only two cases 7 intratumoural lymphatics were identified in the primary tumours of both these cases. Local recurrence occurred in of cases despite complete excision and post-operative radiotherapy the mean time to recurrence was months. Conclusion On the basis of this study we do not advocate sentinel lymph node biopsy in this group of patients except in those cases in which intratumoural lymphatics can be demonstrated. Close follow up is important especially for high grade leiomyosarcomas particularly in the first year as these tumours have a high incidence of local recurrence. Introduction Leiomyosarcoma of soft tissues is a malignant tumour composed of tumour cells that exhibit smooth muscle differentiation. Leiomyosarcomas are generally thought to account for 5-10 of soft tissue sarcomas 1-3 . These tumours arise most .
