Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Gene expression changes with a ‘non-injurious’ ventilation strategy. | Available online http content 13 2 403 Letter Gene expression changes with a non-injurious ventilation strategy Calvin SH Ng1 Song Wan1 Anthony MH Ho2 and Malcolm J Underwood1 1 Division of Cardiothoracic Surgery The Chinese University of Hong Kong Prince of Wales Hospital 30-32 Ngan Shing Street Shatin NT Hong Kong 2Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Prince of Wales Hospital 30-32 Ngan Shing Street Shatin NT Hong Kong Corresponding author Song Wan swan@ Published 4 March 2009 This article is online at http content 13 2 403 2009 BioMed Central Ltd Critical Care 2009 13 403 doi cc7719 See related research by Wolthuis et al. http content 13 1 R1 We read with interest the article by Wolthuis and coworkers 1 who found that mechanical ventilation initiates ventilator-induced lung injury VILI in the absence of a priming pulmonary insult even with least injurious ventilator settings. Furthermore high tidal volume was associated with increased histological and biochemical markers of lung injury 1 . The phenomenon of VILI is well recognized and can be particularly significant in surgical specialties that require large transfusions cardiopulmonary bypass and associated lung ischemia-reperfusion injury 2 3 . Counterintuitively ventilation may be beneficial in specific surgical scenarios in that it may attenuate atelectasis and ischemia-reperfusion injury 4 . Improved understanding of VILI may be gained by studying the response at the genetic level. Microarray analysis allows one to gain an unbiased view of the gene expression signature at a particular time point. Recent work in animal VILI models revealed that a large number of genes in the lung were markedly upregulated by mechanical ventilation including genes involved in immunity and inflammation MIP1 MIP2 IL-1P and IL-6 stress response GADD45-Ỵ and transcription processes IRF-7 ATF-3 5 . Previous studies have .
