Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Hyperglycaemia results from beta-cell dysfunction in critically ill children with respiratory and cardiovascular failure: a prospective observational study. | Available online http content 13 1 R27 Research Hyperglycaemia results from beta-cell dysfunction in critically ill children with respiratory and cardiovascular failure a prospective observational study Catherine M Preissig and Mark R Rigby Emory University School of Medicine Department of Pediatrics Division of Pediatric Critical Care Medicine Children s Healthcare of Atlanta at Egleston 1405 Clifton Road Atlanta GA 30322 USA Corresponding author Catherine M Preissig Received 23 Oct 2008 Revisions requested 2 Dec 2008 Revisions received 16 Dec 2008 Accepted 26 Feb 2009 Published 26 Feb 2009 Critical Care 2009 13 R27 doi cc7732 This article is online at http content 13 1 R27 2009 Preissig and Rigby licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Hyperglycaemia is common in critical illness and associated with poor outcome. Glycaemic control using insulin may decrease morbidity and mortality. Many questions remain about the cause of critical illness hyperglycaemia CIH . Our objective was to investigate the endocrinological basis of paediatric CIH. Methods C-peptide and blood glucose BG levels were assessed in 41 children aged 2 to 18 years old who were admitted to our paediatric intensive care unit PICU . Patients who developed CIH defined as persistent BG above mmol L were treated with insulin infusion to achieve BG levels between and mmol L. C-peptide levels were compared with respect to CIH development and degree of organ failure in all patients. Respiratory and cardiovascular failure were defined as need for mechanical ventilation and need for vasoactive infusions respectively. Clinical and laboratory parameters .
